Blog on LongevityGraph — Your health data, finally connected

How Our 6-Dimension Safety Engine Works

Thu, 26 Mar 2026 00:00:00 +0000

If you’re taking more than a handful of supplements, you’ve probably searched “can I take X with Y?” at some point. The answer you get from a Google search is usually a single-sentence warning with no context about severity, mechanism, or what to do about it.

LongevityGraph’s safety engine approaches this differently. Instead of checking one supplement against one other supplement, it runs a 6-dimension analysis across your entire stack simultaneously.

What Is PhenoAge and How to Calculate Yours

Wed, 25 Mar 2026 00:00:00 +0000

Your chronological age is fixed — it’s how many years you’ve been alive. Your biological age is different. It measures how old your body actually is based on clinical biomarkers, and it can be higher or lower than your calendar age.

PhenoAge, developed by Morgan Levine and colleagues in 2018, is one of the most validated biological age algorithms. It uses 9 routine blood biomarkers that you can get from any standard blood panel.

How We Grade Supplement Brands A Through F

Tue, 24 Mar 2026 00:00:00 +0000

Not all supplement brands are created equal. A bottle of magnesium from an NSF-certified manufacturer with third-party testing and GMP compliance is a fundamentally different product than one from an unverified brand with no testing documentation.

LongevityGraph grades every supplement brand on a deterministic A-F scale. No AI opinions, no subjective reviews — just data.

The Scoring Framework

Our brand quality score evaluates 35+ boolean and tiered attributes across four categories, weighted by their impact on product quality:

200+ Genetic Variants We Analyze — and Why They Matter

Mon, 23 Mar 2026 00:00:00 +0000

When you upload a 23andMe or AncestryDNA raw data file to LongevityGraph, we don’t just look at a handful of popular SNPs. We analyze 200+ longevity-relevant genetic variants across 15 categories. Here’s why each category matters for health optimization.

The Big Three: MTHFR, APOE, and COMT

MTHFR (Methylation)

MTHFR C677T and A1298C are the most discussed variants in the longevity community — for good reason. If you’re homozygous for C677T (about 10-15% of the population), your ability to convert folic acid to its active form (methylfolate) is reduced by up to 70%.

5 Supplement Interactions Most People Miss

Sun, 22 Mar 2026 00:00:00 +0000

If you search “can I take magnesium with iron?” you’ll find the answer quickly. But the interactions that actually harm people aren’t the obvious ones — they’re the contextual ones that depend on your specific medications, conditions, and stack composition.

Here are five interactions that most generic checkers miss.

1. Statin + CoQ10 Depletion (The Silent One)

Every statin (atorvastatin, rosuvastatin, simvastatin, etc.) inhibits HMG-CoA reductase — the same enzyme pathway that produces CoQ10. Over months, this depletes your body’s CoQ10 levels, potentially causing muscle pain, fatigue, and reduced mitochondrial function.