How Our 6-Dimension Safety Engine Works

If you’re taking more than a handful of supplements, you’ve probably searched “can I take X with Y?” at some point. The answer you get from a Google search is usually a single-sentence warning with no context about severity, mechanism, or what to do about it.

LongevityGraph’s safety engine approaches this differently. Instead of checking one supplement against one other supplement, it runs a 6-dimension analysis across your entire stack simultaneously.

The Six Dimensions

Dimension 1: Contraindications

This checks every supplement and medication against your health conditions. If you have a thyroid condition, the engine knows that high-dose biotin can interfere with thyroid function tests. If you’re on blood thinners, it catches vitamin K2 and high-dose omega-3 conflicts.

The engine uses 61 contraindication rules with severity levels from “avoid” (hard stop) to “monitor” (track with blood work).

Dimension 2: Drug-Supplement Interactions

This is the interaction most people think of — does supplement A interfere with medication B? But we go deeper than pairwise checking. The engine understands drug classes. If you’re on a statin (atorvastatin, rosuvastatin, etc.), it knows the entire drug class depletes CoQ10 and will flag this regardless of which specific statin you take.

We maintain 127 interaction rules with drug-class-aware severity adjustments for 30+ medication categories.

Dimension 3: Supplement-Supplement Interactions

Beyond drug interactions, supplements can interfere with each other. Calcium reduces iron absorption by ~40% when taken simultaneously. Zinc competes with copper for absorption. The engine checks every pairwise combination in your stack and recommends specific timing windows to avoid conflicts.

Dimension 4: Dose / Total Daily Load

If you’re taking magnesium in three different supplements, the engine sums the total daily dose across your entire stack and checks it against the NIH Upper Tolerable Intake Level (UL). This catches the slow accumulation that individual product labels can’t warn you about.

Dimension 5: Condition Interactions

This dimension cross-references your diagnosed conditions with your entire supplement and medication stack. Certain supplements that are generally safe become risky with specific conditions — for example, high-dose vitamin E with bleeding disorders, or St. John’s Wort with bipolar disorder. The engine evaluates these condition-specific risks beyond simple contraindication labels.

Dimension 6: Allergen Safety

The engine checks supplement ingredients against your known allergies. This includes not just the active ingredients but also excipients, fillers, and common allergens like soy, gluten, shellfish-derived glucosamine, or dairy-based probiotics. If you’ve reported an allergy, every product in your stack is screened for that allergen.

Beyond Generic Warnings

The key difference is that every finding is contextualized to your specific situation. The engine doesn’t just say “fish oil may interact with blood thinners.” It says “Your fish oil (3g EPA/DHA) at your current dose has a moderate interaction with your warfarin. Your latest INR was 2.4 (in range). Recommendation: monitor INR at next blood draw, consider reducing to 2g if INR trends above 3.0.”

That level of specificity requires connecting your supplement stack to your biomarkers, medications, conditions, and genetics — which is exactly what LongevityGraph does.

Try It Free

You can check your own supplement stack using our free interaction checker. It uses the same safety engine described above, checking your supplements against our database of 127+ interaction rules.